Cáncer: terapias y tratamientos

Una visión diferente sobre el cáncer

Identifican un nuevo gen de la leucemia

Posted by ayudacancer en mayo 8, 2007

T-ALLInvestigadores europeos han identificado un gen relacionado con una forma agresiva de leucemia que afecta principalmente a niños muy pequeños. Esta investigación, en la que participaron científicos de Bélgica, España y Países Bajos, se ha publicado en la edición digital de la revista Nature Genetics.

 

Los glóbulos blancos desempeñan una función importante en nuestro organismo, puesto que se ocupan de combatir intrusos como los virus y las bacterias. Sin embargo, en las personas que padecen leucemia, las células de la médula ósea que deberían convertirse en glóbulos blancos se multiplican descontroladamente y no se desarrollan como deberían. Los glóbulos resultantes no funcionan como deberían, lo que deja al paciente expuesto a sufrir infecciones.

English version available: New player in the development T-cell acute lymphoblastic leukemia

Esta última investigación se centró en la leucemia linfoblástica aguda de las células T (LLA-T), en la que se multiplican muy rápidamente unos glóbulos llamados células T inmaduras. Se trata del tipo de cáncer más común en niños pequeños y afecta sobre todo a niños de dos y tres años de edad. Más de la mitad de los niños afectados se curan con la ayuda de los tratamientos más novedosos, pero continúa la búsqueda de fármacos que beneficien a quienes actualmente no responden bien a la quimioterapia.

Se sabe que la LLA-T se debe a defectos que se dan de forma simultánea en varios genes y la comunidad científica se está esforzando por identificar, por un lado, los genes concretos implicados y, por otro lado, las combinaciones de genes que desencadenan esta enfermedad.

Ahora los científicos han descubierto que un gen llamado MYB influye en el desarrollo de la enfermedad. El gen MYB está implicado en el control de la proliferación, la supervivencia y la diferenciación de las células que se transformarán en glóbulos de sangre. En el 10% de los pacientes con LLA-T del estudio se observó que el gen MYB estaba duplicado. El MYB ya se había asociado a otras formas de cáncer.

Los investigadores suprimieron el gen MYB en las líneas de células de la LLA-T y observaron que esto producía un efecto limitado, pero de importancia terapéutica, en las células cancerosas. No obstante, el efecto era mucho mayor si combinaban la supresión del MYB con la supresión del gen NOTCH1, que está implicado en casi el 70% de todos los casos de LLA-T.

Ya se están probando inhibidores del NOTCH1 en humanos, si bien estos fármacos son extremadamente tóxicos y no todos los pacientes pueden tolerarlos. Los investigadores confían en que este descubrimiento lleve al desarrollo de una terapia nueva combinada específica para los genes MYB y NOTCH1 en la que se reduzca la concentración de inhibidores del NOTCH1.

New player in the development T-cell acute lymphoblastic leukemia

Leukemia, or cancer of the bone marrow, strikes some 700 Belgians each year. Scientists are still searching for the cause of many forms of leukemia, including T-cell acute lymphoblastic leukemia, or T-ALL.

Now, VIB researchers connected to the Katholieke Universiteit Leuven have identified a new player in the development of some 10% of the T-ALL cases: MYB. The scientists have discovered that patients in this group have a duplication of the MYB gene, which increases MYB concentrations. Further research has indicated that MYB might well be an important target for therapies for this group of T-ALL patients.

T-cell acute lymphoblastic leukemia (T-ALL)

Our bodies’ white blood cells combat foreign intruders such as viruses and bacteria. However, in leukemia, the formation of white blood cells is disrupted. The cells in the bone marrow that should develop into white blood cells multiply out of control without fully maturing. These blood cells do not function properly and thus jeopardize the production of normal blood cells. Among other consequences, this makes patients more susceptible to infections. T-ALL is a certain form of leukemia in which immature T-cells (a specific type of blood cells) build up very rapidly. T-ALL is the most prevalent form of cancer in children under 14 years of age, striking children between the ages of 2 and 3 in particular. Today, with optimal treatment using chemotherapy, more than half of the children are cured.

Combined action of several players

The search for the mechanisms that cause T-ALL goes on ceaselessly. Discovering these mechanisms will enable the development of targeted therapies, which are preferred over chemotherapy. Scientists know that T-ALL arises only when defects occur in several genes simultaneously. So it is not only important to identify the genes that underlie T-ALL, but also to discover which combinations trigger the disease. This is an important step in the development of specific combination therapies, which are much more effective than therapies that focus on just one target.

A new player

Idoya Lahortiga and Jan Cools in Peter Marynen’s group, working with colleagues from Ghent (Belgium) and Rotterdam (the Netherlands), have recently identified MYB as a major player in certain T-ALL cases. Studying the DNA of 107 patients, they found that the MYB gene was duplicated in 9 of them. This duplication results in increased MYB concentrations. The MYB transcription factor is important for the proliferation, survival and differentiation of the precursor cells that precede the formation of blood cells. Scientists also know that MYB is involved in several other forms of cancer.

On the way to a new therapy

The researchers are convinced that MYB can be an important target for the development of a new therapy for T-ALL. They are particularly encouraged by the results they obtained when they suppressed the expression of MYB in T-ALL cell lines. This produced a limited – but therapeutically significant – effect on the cancer cells.

They also obtained a much more significant effect by suppressing two genes at the same time: MYB and NOTCH1. NOTCH1 has recently been identified as an important factor in the development of nearly 70% of T-ALL cases. The effect of inhibiting NOTCH1 is currently being tested on T-ALL patients. This is going very well, but the NOTCH1 inhibitors turn out to have toxic side effects, whereby some patients have to stop the treatment. The results from the VIB researchers in Leuven now demonstrate that the combined inhibition of NOTCH1 and MYB in T-ALL cell lines is very effective. These results raise hopes that scientists will be able to develop a very effective combination therapy – in which the concentration of the toxic NOTCH1 inhibitors is reduced – for the group of patients in which MYB and NOTCH1 play a role. The quest for this therapy will also be a part of the further research efforts of Lahortiga, Cools and Marynen.

29 comentarios to “Identifican un nuevo gen de la leucemia”

  1. cleark said

    hola quiero saber con que virus tiene relacion la leucenia

  2. estron / tengo leucemia m cronicame gustaria tomarla conoci un amigo que la toma lo veo muy bien la compañia se la regala te pido a dios que me la regale la tiene enprueba yo soy una candidata para eso en 3meses el amigo la esta tomando esta muy recuperado x favor ya me tiene correo vivo en venezuela ayudame x favor

  3. clara vidal said

    Nuestro hio de 3 años padece LLA tipo T. Tuvo recaída precoz y es refractario a todo tipo de quimioterapia. Quisiera saber como podria beneficiarse de este nuevo hayazgo que actualmnte estan desarrollando la dra Lahortiga y Jan Cools para el desarrollo de inhibidores de los genes NOTCH1 y MYB. Si no ocurre nada mejor antes Raúl serà preparado para trasplante con una remisión parcial de hasta el 20% puesto que no se ha logrado más. Esto significa que las posibilidades de éxito son francamente escasas.

    Muchas gracias por vuestra atención

    Clara Vidal

  4. Anónimo said

    nbo se que hacer con la leucemia

  5. karen jara said

    ME GUSTARIA QUE TODOS QUE TENGAN DUDAS ACERCA UN TEMA DE SALUD ME DEJAR SU CORREO, PARA QUE PODAMOS HABLAR DIRECTAMENTE, CUIDENSE, MI CORREO ES for_ever1735@hotmail.com

  6. Roxana said

    hola quiero saber sobre leucemia neutrofilica cronica que ataco a una joven de 18 años desencadenando un sarcoma en el cuello y murio en menos de una semana.

  7. espero que todas las personas del mundo que sufren de leucemia se curen para que puedan tener una sonrisa de alegria.

  8. ghdgtr5y6

  9. espero que todas las personas del mundo que sufren de leucemia se curen para que puedan sonreir sin tener preocupacxión por su enfermedad

  10. espero que todas las personas del mundo que sufren de leucemia se curen para que puedan sonreir sin tener preocupación por su enfermedad

  11. magaly ramirez said

    Hola ,quisiera saber si siguen haciendo las pruebas soy amiga de la mama de un nino que le regreso la leucemia desgraciadamente ,tienen que hacerle un trasplante de medula osea y es muy riesgozo puesto que hay que esperar a que haya un donante y eso puede tardar muchisimo…… tiempo ,mientras el sigue creando pues celulas cancerigenas , tenemos confianza en nuestro creador,que el mandara una respuesta .

  12. luz stella said

    Señor: RICK HUNTER.Gracias por su respuesta,por favor dìgame que clase de frutas puede y no puede comer un niño con leucemia linfoblàstica.El niño està siendo tratado en un hospital de Madrid,por favor dìgme si hay la càmara hyperbàryca en Madrid y dònde por favor.Que Dios le de muchas bendiciones por la ayuda que nos presta a travès de èste sitio.Muchas gracias.

  13. Rick Hunter said

    Hola Luz, no te puedo indicar una selección de frutas ya que la pediatria no es mi especialidad, solo te puedo decir que las frutas no deben ser una complicación sino una ayuda, la mayoria de las frutas es benefica para todas las edades y personas, asi pues la manzana, la pera, las uvas, el platano, duraznos, son beneficos acá en México contamos con la guanabana que es especialmente recomendada para las dietas anticancer creo que haya le llaman graviola, además el uso de frutos secos como nueces, pepitas de calabaza, almendras es muy benefico, igual verduras y hortalizas como la zanahoria, la jicama, ya sea en jugo o en ensalada son magnificos, el higado de pollo, caldo de res, nutren; creo que esto te puede orientar, sobre lo de la camara hiperbarica en Madrid te dejo estos links para que investigues:
    link1.-http://www.institutobiologico.com/terapias/hiperbarica.htm

    link2.-http://www.dsalud.com/numero41_4.htm

    link3.-http://www.mar-ivysub.com/CCCMH.htm

    Recuerda asesorarte bien si el pequeño es suceptible de recibir la terapia y en que condiciones, finalmente ya que tu vives en España debes de tener acceso al Renoven/BioBac que es un preparado originario de tu pais y que ha demostrado sus beneficios anticancer
    link:http://www.amatusalud.es/producto/renoven-antiguo-biobac

    Pues espero esto te sirva y que todo les marche bien, gracias por las bendiciones de igual forma bendigo el bien para uds.

  14. jrff said

    quiero saber si la guanabana es buena para la leucemia

  15. Marta Tolosa said

    Cordial saludo hace un mes le diagnosticaron a mi sobrino de 20 años leucemia linfoide aguda con antigenmos miloides CD33 me gusataria saber si este medicamento podria ser util para su tratamiento ya que se suspendio la quimioterapia por una infeccion severa en la pierna derecha. es posible que me informen cual es el `pais que tiene estudios mas actualizados sobr e la leucemia gracias por sus respuesta.

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  24. Hello this is kinda of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding skills so I wanted to get advice from someone with experience. Any help would be greatly appreciated!

  25. lucila torres garcia said

    Lucy
    julio 19, 2014
    Hola, tengo una hermana que tiene anemia plasmica, y necesito apoyo.

  26. lucila torres garcia said

    Hola tengo una hermana que tiene una enfermedad llamada anemia plasmica; al parecer es una nueva enfermedad de la sangre, las plaquetas funcionan mal y los globulos rojos se ven deteriorando; por lo que cada semana, hay que tranfundirle sangre y plaquetas, su costo es muy caro, los donadores somos los familiares, aparte de esto toma un medicamento llamado ciclosporina que tiene un valor de $22,000 pesos y es para cada mes; nos estamos quedando sin dinero y sin propiedades, mientras le hacemos la transplante de medula, la cual el medico nos informo que juntemos más de 700,000 pesos para los estudios y el transplante; los hospitales de gobieno no lo hacen; es por eso que pido ayuda economica, o que me informen donde puedo comprar la ciclosporina barata y que asociación nos puede ayudar; ya que es urgente, su cuerpo no tolerará mas transfusiones y nuestros recursos se estan agotando.

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